近日，国家传染病医学中心主任、复旦大学附属华山医院感染科主任张文宏表示，当前我国已具备利用二代测序（NGS）技术有效检测尼帕病毒的能力。尼帕病毒是一种高致死率的人畜共患病毒，主要通过果蝠传播，曾在东南亚多国引发疫情。由于其症状初期与流感相似，早期诊断难度较大，因此快速、准确的检测手段至关重要。张文宏指出，二代测序技术具有高通量、高灵敏度和无需预设病原体信息的优势，可在未知病原体暴发时迅速识别病毒基因组序列。这意味着即使面对新型或罕见病毒，如尼帕病毒，也能在短时间内完成鉴定，为疫情防控争取宝贵时间。此外，我国近年来在病原微生物监测网络和实验室能力建设方面持续投入，已形成覆盖全国的快速响应体系。专家强调，尽管目前中国尚未报告尼帕病毒感染病例，但全球人员流动频繁，输入性风险始终存在。因此，加强边境检疫、提升基层医疗机构识别能力，并依托先进测序技术构建预警机制，是防范新发传染病的关键举措。
Recently, Dr. Zhang Wenhong, Director of the National Center for Infectious Diseases and Head of the Department of Infectious Diseases at Huashan Hospital affiliated with Fudan University, stated that China now has the capability to effectively detect Nipah virus using next-generation sequencing (NGS) technology. The Nipah virus is a highly lethal zoonotic pathogen primarily transmitted by fruit bats and has caused outbreaks in several Southeast Asian countries. Its early symptoms resemble those of influenza, making timely diagnosis challenging—hence the critical need for rapid and accurate detection methods.Dr. Zhang emphasized that NGS offers high-throughput, high-sensitivity analysis without requiring prior knowledge of the pathogen, enabling swift identification of viral genomes during emerging outbreaks. This means that even novel or rare viruses like Nipah can be identified within days, providing crucial time for public health responses. In recent years, China has significantly invested in pathogen surveillance networks and laboratory infrastructure, establishing a nationwide rapid-response system.Although no Nipah virus cases have been reported in China to date, experts warn that frequent global travel poses ongoing importation risks. Strengthening border quarantine, enhancing frontline clinicians’ diagnostic awareness, and leveraging advanced sequencing technologies for early warning systems are essential strategies to combat emerging infectious diseases.
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